Hydrochlorothiazide: The most typical indicators and signs of overdose observed in human beings are These due to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from extreme diuresis.
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Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to your AT1 angiotensin II receptor. There is also an AT2 receptor in several tissues, but It's not necessarily associated with cardiovascular homeostasis.
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The choice of Irbesartan & Hydrochlorothiazide tablets as Preliminary therapy for hypertension should be dependant on an assessment of prospective Added benefits and threats.
Angiotensin II would if not bind for the AT1 receptor, inducing vasoconstriction and aldosterone secretion, boosting blood pressure level.
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